Abstract for presentation at Australian and New Zealand Association of Neurologists Annual Scientific Meeting 2008

Brain Amyloid Imaging with 11C-PIB PET

  • Dr Steven Ng, Austin Hospital PET Centre, Australia
  • Dr Victor Villemagne, Austin Hospital PET Centre, Australia
  • Dr Sylvia Gong, Austin Hospital PET Centre, Australia
  • Dr Graeme O'Keefe, Austin Hospital PET Centre, Australia
  • Dr Henri Tochon-Danguy, Austin Hospital PET Centre, Australia
  • Dr Uwe Ackermann, Austin Hospital PET Centre, Australia
  • Dr Colin Masters, Pathology Department, University of Melbourne, Australia
  • Dr Christopher Rowe, Austin Hospital PET Centre, Australia

    • Objectives: To assess cerebral beta-amyloid (Aβ) deposition in a variety of dementias using 11C-PIB positron emission tomography (PET) and to evaluate the diagnostic accuracy of this technique.
    Methods: 32 healthy controls (HC) (age:71±7; MMSE:>28), 35 Mild cognitive impairment (MCI) subjects (age:71±9; MMSE:26.8±2), 40 subjects with mild to moderate AD (age:74±10; MMSE: 21.7±4), 12 Dementia with Lewy Bodies (DLB) (age:72±6, MMSE:20.9±7), and 10 Frontotemporal dementia (FTD) (age:68±10, MMSE:24.5±3) underwent 11C-PIB PET. Aβ burden was quantified using Standardized Uptake Value normalized to cerebellar cortex (SUVR). The neocortical SUVR was used for analysis. Results: Neocortical SUVR was 1.40±0.33 in HC, 1.84±0.59 in MCI, 2.42±0.33 in AD, 1.90±0.36 in DLB, and 1.22±0.17 in FTD. At a SUVR threshold of 1.6 (the 75th percentile of HC), cortical PIB binding was present in 100% of AD, 60% of MCI, 23% of HC, 85% of DLB, and none of the FTD. A correlation between Aβ burden and cognition was observed in the MCI cohort (MMSE: r =-0.33, P<0.05; CVLT II: r =-0.53, P<0.001). Both visual and quantitative analyses revealed PIB a more accurate test than 18F-FDG PET (Accuracy: 90% vs.70%) for detection of AD especially in older onset cases. Conclusions: Our data supports a pathogenic role for Aβ accumulation in AD by showing a relationship to mild cognitive impairment. PIB PET can assist differential diagnosis of dementia.

    Conference Organiser - ICMS Pty Ltd