Aims: To examine predictive and explanatory factors for burden in caregivers of people with dementia or mild cognitive impairment (MCI) who are living at home. Methods: 323 patients with MCI or dementia enrolled in PRIME (Prospective Research In MEmory clinics) with complete data at baseline and 6 months were included in these analyses. Multiple linear regression models were applied to the data, examining correlations of Zarit Burden Inventory (ZBI) scores at month six and change in ZBI with caregiver sex, caregiver employment status, living arrangements, service usage, psychotropic medication usage, Neuropsychiatric Index (NPI), Clinical Dementia Rating, Mini Mental State Examination, ZBI, and Functional Autonomy Measurement System. Results: Month six ZBI was significantly predicted by: female caregivers (Coeff= 3.95, p=0.002), employment status (Coeff= -4.17, p= 0.029), MMSE at baseline (Coeff= -0.34, p=0.032), ZBI at baseline (Coeff= 0.70, p <0.001), living with spouse (Coeff= -4.16, p=0.043), service usage (Coeff= 2.74, p=0.037) and psychotropic medication usage at baseline (Coeff= 2.48, p=0.045). Change in ZBI was significantly associated with female caregivers (Coeff=3.50, p=0.002), change in NPI (Coeff=0.19, p<0.0001), baseline ZBI (Coeff=-0.29, p<0.0001), change in SMAF(Coeff=-0.51, p<0.0001), patient living alone (Coeff=-5.23, p=0.028) and use of psychotropic medications (Coeff=2.26, p=0.038). Conclusions: Being a female caregiver, unemployed, high baseline MMSE, high baseline ZBI, service usage, living arrangement and psychotropic medication use at baseline predicted higher caregiver stress after 6 months. Increasing behavioural disturbance, decreasing functionality, female caregivers, higher baseline ZBI, living with the patient and psychotropic medication use were associated with increasing caregiver burden.